![]() One animal study concluded that vervain root extract significantly delayed the volume and frequency of diarrhea, compared with a control ( 20). A study in rats determined that treatment with verbenalin, or cornin, reduced heart tissue death and damage from inadequate blood supply ( 19). One study in 260 people suggests that a vervain decoction (herbal infusion) may benefit the management of chronic gingivitis or gum inflammation ( 18). The topical use of vervain extract seems to have an anti-inflammatory effect on swelling caused by fluid retention ( 17). Vervain’s extract and essential oils may provide other potential health benefits, such as: However, studies in humans are still needed ( 16). Research suggests that flavonoids may inhibit bacterial attachment to the host and neutralize toxicity against human cells. Additionally, other beneficial compounds like flavonoids, which are present in the plant, may add to these effects ( 15). Similarly, another test-tube study demonstrated the antibacterial effect of vervain extract against Staphylococcus aureus, Escherichia coli, and Salmonella typhi, which are responsible for multiple infectious diseases ( 14).Ĭompounds in vervain essential oil, such as citral, are known to possess antimicrobial activities. It inhibited the growth of all microorganisms in a dose-dependent manner - meaning that the higher the dose, the higher the antimicrobial effect ( 13). In one test-tube study, vervain essential oil was tested against two fungi and seven bacteria. Promisingly, studies show that vervain may protect against antibiotic-resistant bacteria and fungi. May have antimicrobial activityĪntibiotic resistance is a growing global concern. Verbenin was even favored over bromide, a compound usually used in epilepsy treatment ( 11). ![]() This was attributed to verbenin, an essential component in vervain. Other studies in rats have concluded that the extract may help manage convulsions or seizures in those with neurological diseases such as epilepsy by prolonging their onset time and shortening their duration ( 11, 12). Researchers linked this to the plant’s content of flavonoids and tannins, both of which are known to possess anti-anxiety and sedative properties. Vervain has long been used in folk medicine as a relaxant or nerve tonic, and animal research currently backs up this use.Ī study in rats determined that doses of 0.04–0.22 grams per pound (0.1–0.5 grams per kg) of body weight of vervain extract had an anxiety-reducing effect comparable to diazepam, a popular drug used to reduce anxiety ( 11). The accumulation of this compound is an important toxic factor involved in the development of the disease ( 10). Research suggests that it may reduce the toxicity of beta-amyloid, or Abeta, peptide. What’s more, the extract may protect against the loss of brain cells or neurons in Alzheimer’s disease. Thus, verbenalin ensures sufficient energy and blood supply to the brain, improving function after a stroke. Without oxygen, energy production decreases, leading to issues in regular cellular activity and potentially the development of many diseases of the nervous system ( 9). ![]() Mitochondria are in charge of energy production in your cells, and they need oxygen to do so. The studies explain that the compound promotes the development of new blood vessels in the brain - which supply it with oxygen - and improves its mitochondrial function. Studies in rats show that vervain’s glycoside verbenalin - also known as cornin - may significantly improve brain damage after a stroke ( 6, 7, 8). Vervain extract may benefit certain neurological or brain-related conditions. Nonetheless, human research is needed to verify these claims. One test-tube study found that a concentration of 0.01% vervain essential oil increased the death of rogue immune cells obtained from those with chronic lymphocytic leukemia from 15–52%, suggesting that it may be useful for the development of new therapeutic agents ( 4). Researchers attributed this anti-tumor activity to verbenosides A and B - two types of glycosides - and triterpenoids ( 3).Īdditionally, citral - a key component in vervain essential oil - possesses proven anticancer effects that cause programmed cell death ( 5). In a mouse study, high doses of vervain extract of 18 grams per pound (40 grams per kg) of body weight inhibited tumor growth by more than 30%, compared with controls. Test-tube and animal studies suggest that vervain’s glycosides, triterpenoids, and essential oils may help inhibit tumor growth and induce the death of cancerous cells ( 3, 4). Vervain contains over 20 beneficial plant compounds, including iridoid glycosides, flavonoids, and triterpenoids, which may be responsible for its purported benefits ( 2).
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